Müller-Hermelink H K, Greiner A
Pathologisches Institut, Universität Würzburg.
Verh Dtsch Ges Pathol. 1992;76:96-109.
During the recent decade evidence accumulated, that autoantibodies exist with a high frequency in the normal B-cell repertoire. The autoreactive B-cell repertoire may undergo malignant transformation through the continuous challenge by autoantigen. Previous work on human paraproteins of plasmocytoma and immunocytoma has shown that a high proportion of paraproteins bind to self determinants. B-cell lymphoma may mimic the lesions in organotropic autoimmune disease, eg. Sjögren's disease, Hashimoto's thyroiditis and coeliac disease by the neoplastic expansion of autoimmune receptors. Considerable evidence has been obtained, that the specific receptor interactions of the lymphoma with the autoantigen may be of functional significance. More precise knowledge on receptor specificities would permit new approaches to the understanding and manipulation of autoimmune disease and lymphoma.
在最近十年间，有证据不断积累表明，自身抗体在正常B细胞库中高频存在。自身反应性B细胞库可能会因自身抗原的持续刺激而发生恶性转化。先前针对浆细胞瘤和免疫细胞瘤患者副蛋白的研究表明，很大一部分副蛋白能与自身抗原决定簇结合。B细胞淋巴瘤可能会通过自身免疫受体的肿瘤性增殖来模仿器官特异性自身免疫性疾病的病变，例如干燥综合征、桥本甲状腺炎和乳糜泻。已有大量证据表明，淋巴瘤与自身抗原的特异性受体相互作用可能具有功能意义。对受体特异性的更精确了解将有助于采用新方法来理解和控制自身免疫性疾病及淋巴瘤。
