Frydecka I, Nowicka J, Slesak B, Radomyska W
Department of Hematology, Medical Academy of Wrocław.
Acta Haematol Pol. 1992;23(2):117-21.
We report a case of a 55-year-old male with lymphoproliferative disease of granular lymphocytes. In the first year of follow-up reactive expansion of granular lymphocytes was observed during infectious episodes additionally to malignant proliferation. Histopathological studies revealed malignant lymphocytic infiltrations of the liver and gallbladder walls. The number of GL varied from 1.1 G/l to 17.8 G/l. Immunophenotyping studies showed surface phenotype CD3+, CD8+. There was markedly reduced NK cell function. The patient exhibited lack of severe parenchymal involvement, moderately increased white cell count (up to 21.0 G/l), severe neutropenia (0.06 G/l - 0.8 G/l) and recurrent infectious episodes.
我们报告一例55岁男性颗粒淋巴细胞淋巴增殖性疾病。在随访的第一年，除恶性增殖外，在感染发作期间观察到颗粒淋巴细胞反应性扩增。组织病理学研究显示肝脏和胆囊壁有恶性淋巴细胞浸润。颗粒淋巴细胞数量从1.1 G/l到17.8 G/l不等。免疫表型研究显示表面表型为CD3+、CD8+。自然杀伤细胞功能明显降低。患者表现为无严重实质受累、白细胞计数中度升高（高达21.0 G/l）、严重中性粒细胞减少（0.06 G/l - 0.8 G/l）和反复感染发作。
