Sano M, Shimamoto Y, Tanaka H, Matsuzaki M, Ono K, Yamaguchi M
Department of Internal Medicine, Saga Medical School.
Rinsho Ketsueki. 1990 Jan;31(1):105-9.
A case of granular lymphocyte proliferative disorder with squamous cell carcinoma of penis is described. A 77-year-old Japanese male was admitted to our hospital in March, 1989 because of ulceration of penis and lymphocytosis. He had hepatomegaly and lymphadenopathy but not splenomegaly on physical examination. The WBC count was 10800/microliters with 83% of granular lymphocytes. Thrombocytopenia (32000/microliters) and mild anemia were also demonstrated. Bone marrow aspirate showed hypercellular marrow with 84% of granular lymphocytes. Proliferative granular lymphocytes were CD2+ CD3+ CD4- CD8- CDw29+ and exhibited ADCC activity but not NK activity. On March 15, amputation of penis was performed. But his lymphocytosis didn't change and thrombocytopenia increased. Thus we considered his granular lymphocytosis was neoplastic rather than reactive. Our case seemed to be rare and was compared with previous reports.
本文描述了一例阴茎鳞状细胞癌合并颗粒淋巴细胞增殖性疾病的病例。一名77岁的日本男性因阴茎溃疡和淋巴细胞增多于1989年3月入住我院。体格检查发现他有肝肿大和淋巴结病，但无脾肿大。白细胞计数为10800/微升，其中颗粒淋巴细胞占83%。还发现有血小板减少（32000/微升）和轻度贫血。骨髓穿刺显示骨髓细胞增多，颗粒淋巴细胞占84%。增殖的颗粒淋巴细胞CD2 +、CD3 +、CD4 -、CD8 -、CDw29 +，具有ADCC活性但无NK活性。3月15日，进行了阴茎截肢术。但他的淋巴细胞增多症没有改变，血小板减少症加重。因此，我们认为他的颗粒淋巴细胞增多是肿瘤性的而非反应性的。我们的病例似乎很罕见，并与先前的报道进行了比较。
