Man Irene, McKinlay Jayne, Dawe Robert S, Ferguson James, Ibbotson Sally H
Photobiology Unit, Department of Dermatology, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland.
J Am Acad Dermatol. 2003 Jul;49(1):59-64. doi: 10.1067/mjd.2003.419.
Limited work has been conducted on the characteristics of topical trimethylpsoralen (TMP) psoralen-UVA (PUVA) erythema.
We sought to determine the time-course and dose-response characteristics of erythema induced by topical TMP, and to compare these parameters with those for topical 8-methoxypsoralen (MOP) within patients.
After photosensitization of one forearm with topical TMP, test sites were exposed to a UVA dose series. The procedure was repeated on the other forearm using 8-MOP solution. Erythema was assessed visually and with a reflectance instrument every 24 hours for 7 days.
TMP PUVA erythema followed a similar time course to 8-MOP PUVA erythema. The majority of patients were at maximal erythema at or beyond 96 hours. TMP PUVA had a significantly steeper dose-response curve at 48, 72, and 96 hours compared with 8-MOP PUVA.
On the basis of these data, the optimal time to read the TMP minimal phototoxic dose is 96 hours. In view of the steeper dose-response curve for TMP PUVA, a lower UVA incremental regimen should be considered compared with that for 8-MOP PUVA.
关于外用三甲补骨脂素（TMP）-补骨脂素-长波紫外线（PUVA）红斑特征的研究较少。
我们试图确定外用TMP诱导红斑的时间进程和剂量反应特征，并在患者体内将这些参数与外用8-甲氧基补骨脂素（MOP）的参数进行比较。
用外用TMP对一侧前臂进行光敏化后，将测试部位暴露于一系列UVA剂量下。另一侧前臂用8-MOP溶液重复该过程。连续7天，每24小时通过视觉和反射仪评估红斑情况。
TMP-PUVA红斑的时间进程与8-MOP-PUVA红斑相似。大多数患者在96小时及以后出现最大红斑。与8-MOP-PUVA相比，TMP-PUVA在48、72和96小时的剂量反应曲线明显更陡。
基于这些数据，读取TMP最小光毒性剂量的最佳时间为96小时。鉴于TMP-PUVA的剂量反应曲线更陡，与8-MOP-PUVA相比，应考虑采用更低的UVA递增方案。
