Crum Nancy F, Lederman Edith R, Hale Braden R, Lim Matthew L, Wallace Mark R
The Internal Medicine Department, Infectious Diseases Division, Naval Medical Center San Diego, San Diego, CA, USA.
Mil Med. 2003 Jun;168(6):460-4.
We recently evaluated a cluster of cases of disseminated coccidioidomycosis referred to the Naval Medical Center San Diego. Between March and June of 2002, seven cases were diagnosed and treated. In a 5-year record review (March 1997-February 2002), we found only seven cases of disseminated disease attributable to Coccidioides immitis at the same institution. This report of seven cases over a 3-month period represents a 20-fold increase in the number of complicated C. immitis infections. All cases were non-Caucasians, had disseminated disease to bone and/or skin without meningeal involvement, and had a delay of 1.5 to 6 months from symptom onset until the diagnosis of coccidioidomycosis. Four of our cases occurred in previously healthy, young active duty members, emphasizing the importance of this mycosis in U.S. military personnel.
我们最近评估了转诊至圣地亚哥海军医疗中心的一组播散性球孢子菌病病例。2002年3月至6月期间，确诊并治疗了7例病例。在一项为期5年的记录回顾（1997年3月至2002年2月）中，我们发现在同一机构仅有7例由粗球孢子菌引起的播散性疾病病例。这份关于3个月内7例病例的报告显示，复杂的粗球孢子菌感染病例数量增加了20倍。所有病例均为非白种人，疾病播散至骨骼和/或皮肤，无脑膜受累，从症状出现到球孢子菌病诊断的延迟时间为1.5至6个月。我们的4例病例发生在之前健康的年轻现役军人身上，强调了这种真菌病在美国军事人员中的重要性。
