衣霉素诱导非洲爪蟾卵母细胞中谷氨酸受体功能表达的抑制。
Tunicamycin-induced inhibition of functional expression of glutamate receptors in Xenopus oocytes.
作者信息
Musshoff U, Madeja M, Bloms P, Müsch-Nittel K, Speckmann E J
机构信息
Institut für Physiologie, Münster, FRG.
出版信息
Neurosci Lett. 1992 Dec 7;147(2):163-6. doi: 10.1016/0304-3940(92)90585-u.
The effects of tunicamycin, a specific inhibitor of N-linked glycosylation, on functional expression of glutamate receptor subtypes were investigated in RNA-injected oocytes. In the presence of tunicamycin the expression of ligand-operated receptors sensitive to kainate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and quisqualate were completely blocked. The inhibitory effect was reversible after removal of tunicamycin from the culture medium.
衣霉素是一种N-连接糖基化的特异性抑制剂，我们在注射了RNA的卵母细胞中研究了其对谷氨酸受体亚型功能表达的影响。在存在衣霉素的情况下，对红藻氨酸、α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）和喹啉酸敏感的配体门控受体的表达被完全阻断。从培养基中去除衣霉素后，这种抑制作用是可逆的。
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