Strauss Erich C, Warren John F, Margolis Todd P, Holsclaw Douglas S
Department of Ophthalmology, University of California San Francisco Medical Center, California, San Francisco, USA.
Am J Ophthalmol. 2003 Jul;136(1):207-9. doi: 10.1016/s0002-9394(03)00081-3.
To report a case initially assessed as giant papillary conjunctivitis and subsequently as B-cell lymphoma by the molecular technique of polymerase chain reaction heteroduplex analysis.
Observational case report.
Clinical, histologic, immunohistochemical, and polymerase chain reaction heteroduplex analysis findings are presented.
A 32-year-old man developed unilateral blepharoptosis secondary to an extensive palpebral conjunctival follicular-like process. Excisional biopsy showed a dense small lymphocyte infiltrate consistent with benign lymphoid hyperplasia by histology and immunohistologic marker studies. Polymerase chain reaction heteroduplex analysis revealed low-grade B-cell lymphoma, however. Systemic examination was negative. Focal radiation therapy was performed, and preliminary results show no signs of lymphoma.
Polymerase chain reaction heteroduplex analysis established a diagnosis of conjunctival B-cell lymphoma in the absence of supporting histology and immunohistochemistry studies. This technique may provide independent, diagnostic distinction between benign lymphoid hyperplasia and low-grade B-cell lymphoma of the ocular adnexa.
报告一例最初被评估为巨乳头性结膜炎，随后通过聚合酶链反应异源双链分析分子技术诊断为B细胞淋巴瘤的病例。
观察性病例报告。
呈现临床、组织学、免疫组织化学及聚合酶链反应异源双链分析结果。
一名32岁男性因广泛的睑结膜滤泡样病变继发单侧上睑下垂。切除活检显示密集的小淋巴细胞浸润，组织学和免疫组织学标志物研究结果符合良性淋巴组织增生。然而，聚合酶链反应异源双链分析显示为低度B细胞淋巴瘤。全身检查结果为阴性。进行了局部放射治疗，初步结果显示无淋巴瘤迹象。
在缺乏支持性组织学和免疫组织化学研究的情况下，聚合酶链反应异源双链分析确诊为结膜B细胞淋巴瘤。该技术可能为眼附属器良性淋巴组织增生和低度B细胞淋巴瘤提供独立的诊断区分。
