Ask the doctor. I am 75 and have had atrial fibrillation for a while. I take digoxin, lisinopril, Coumadin, and Lipitor. My medications seem to work, but I'm still concerned about the big difference between my systolic and diastolic blood pressure readings. The systolic is usually between 130 and 150 and the diastolic is between 55 and 70. Should I worry about this?