Leyton M, Rajabi H, Stewart J
Douglas Hospital Research Center, Department of Psychiatry, McGill University, Verdun, Québec, Canada.
Neuroreport. 1992 Dec;3(12):1127-30. doi: 10.1097/00001756-199212000-00024.
Injections of kappa (k) opioid agonists into the A10 ventral tegmental area (VTA) induce behavioral inhibitions and decreased interest in incentive stimuli, behavioral changes indicative of decreased mesolimbic dopamine (DA) transmission. In seeming contrast, three separate laboratories have recently reported that intra-VTA injections of k agonists do not affect nucleus accumbens septi (NAS) basal levels of extracellular DA. In the present experiment, we investigated whether intra-VTA injections of a k agonist would decrease pharmacologically-stimulated increased levels of extracellular NAS DA. It was found that intra-VTA injections of the k agonist U-50,488H significantly attenuated haloperidol-induced elevations of DA, as measured by in vivo microdialysis.
向A10腹侧被盖区（VTA）注射κ（k）阿片类激动剂会引发行为抑制，并降低对激励刺激的兴趣，这些行为变化表明中脑边缘多巴胺（DA）传递减少。看似矛盾的是，最近有三个独立的实验室报告称，向VTA内注射k激动剂不会影响伏隔核（NAS）细胞外DA的基础水平。在本实验中，我们研究了向VTA内注射k激动剂是否会在药理学刺激下降低细胞外NAS DA升高的水平。结果发现，通过体内微透析测量，向VTA内注射k激动剂U-50,488H可显著减弱氟哌啶醇诱导的DA升高。
