Golub Mari S, Germann Stacey L, Keen Carl L
Department of Internal Medicine, University of California, Davis, CA 95616, USA.
Biol Trace Elem Res. 2003 Summer;93(1-3):213-26. doi: 10.1385/BTER:93:1-3:213.
Female Swiss Webster mice were fed diets containing 7 (control) or 1000 microg Al/g diet from conception to weaning. Pregnancy weight gain, birth weight, litter size, postnatal mortality, and weaning weight were measured. In different groups, diets low in Fe, Zn, P, or Ca and Mg (CaMg) were used as basal diets, to which Al was added. Relative to controls, who received NRC recommended levels of these nutrients, all diets with marginal essential trace elements impacted development, as demonstrated by effects on birth weight (CaMg, Fe) or weaning weight (Fe, Zn, P). Compared to diets low in Al, the 1000-mg Al/g diet led to reduced weaning weight regardless of the essential element content of the diet. Other end points were influenced by Al only within the basal diet group; pregnancy weight gain with the low-P diet, litter size with the low-Fe diet, pregnancy completion with the low-Zn diet, and postnatal mortality with the low-CaMg or low-Zn diet. Thus, diets marginal in selected minerals can differentially alter the toxicological profile of developmental Al exposures. A basal diet was also used in which the NRC diet was supplemented with ascorbic acid, which promotes Al absorption. No modification of Al toxicity was seen with ascorbic acid supplementation.
从受孕到断奶期间，给雌性瑞士韦伯斯特小鼠喂食含7（对照）或1000微克铝/克食物的饲料。测量怀孕体重增加、出生体重、窝仔数、产后死亡率和断奶体重。在不同组中，使用低铁、锌、磷或钙镁（CaMg）的饲料作为基础饲料，并添加铝。与接受美国国家研究委员会（NRC）推荐水平这些营养素的对照组相比，所有含边缘必需微量元素的饲料都会影响发育，这体现在对出生体重（CaMg、铁）或断奶体重（铁、锌、磷）的影响上。与低铝饲料相比，无论饲料中必需元素含量如何，1000毫克铝/克的饲料都会导致断奶体重降低。其他终点指标仅在基础饲料组中受铝的影响；低磷饲料组的怀孕体重增加、低铁饲料组的窝仔数、低锌饲料组的怀孕完成情况以及低CaMg或低锌饲料组的产后死亡率。因此，某些矿物质含量处于边缘水平的饲料会不同程度地改变发育过程中铝暴露的毒理学特征。还使用了一种基础饲料，即在NRC饲料中添加促进铝吸收的抗坏血酸。补充抗坏血酸后未观察到铝毒性的改变。
