Regenthal R, Voigt H, Preiss R
Institut für Klinische Pharmakologie, Universität Leipzig.
Z Gesamte Inn Med. 1992 Dec;47(12):573-82.
The important group of drugs known as calcium antagonists is surveyed from a clinico-pharmacological viewpoint. The recently introduced substances are presented in a detailed manner. Common features and differences in pharmacodynamics and pharmacokinetics of the individual calcium antagonists are explained and their differential therapeutic use in the treatment of chronic cardiovascular diseases is discussed. The article also reports on drug interferences, contraindications and possible extensions of indications. An assessment is made of results achieved so far when applying calcium antagonists in the treatment of chronic cardiovascular diseases and in the prevention of arteriosclerosis.
从临床药理学角度对重要的一类药物——钙拮抗剂进行了综述。详细介绍了最近引入的药物。解释了各钙拮抗剂在药效学和药代动力学方面的共同特征和差异，并讨论了它们在慢性心血管疾病治疗中的不同治疗用途。本文还报道了药物相互作用、禁忌症及可能的适应症扩展。对目前应用钙拮抗剂治疗慢性心血管疾病和预防动脉硬化所取得的结果进行了评估。
