Kropácová K, Misúrová E
Department of Cellular and Molecular Biology, Safárik University, Kosice.
Physiol Res. 1992;41(2):135-40.
The effect of aging (2-14 months) and total body irradiation (5.7 Gy of gamma radiation) on liver regeneration was investigated in rats 30 h after partial hepatectomy. Exposure of rats to irradiation 30 min before partial hepatectomy caused latent injury in the remaining liver cells. During the course of liver regeneration this became manifested as a delay in increasing the nucleic acid concentration and content and liver weight and, furthermore, as inhibition of the increase in the mitotic index and cellularity and pronounced increase in the frequency of chromosome aberrations in the postmetaphase. The pattern of age-related changes during liver regeneration was the same as that after irradiation, so that the differences between irradiated and nonirradiated animals became smaller with age.
在大鼠部分肝切除术后30小时，研究了衰老（2 - 14个月）和全身照射（5.7 Gyγ射线）对肝脏再生的影响。在部分肝切除术前30分钟对大鼠进行照射，会对剩余肝细胞造成潜在损伤。在肝脏再生过程中，这表现为核酸浓度、含量及肝脏重量增加延迟，此外还表现为有丝分裂指数和细胞数量增加受到抑制，以及中期后染色体畸变频率显著增加。肝脏再生过程中与年龄相关的变化模式与照射后相同，因此随着年龄增长，照射组与未照射组动物之间的差异变小。
