Kropácová K, Misúrová E, Haková H
Department of Cellular and Molecular Biology Faculty of Sciences, University of P. J. Safárik, Kosice, Slovakia.
Radiats Biol Radioecol. 1998 May-Jun;38(3):411-5.
Radioprotective and therapeutical effect of silymarin (Flavobion) on development and repair of latent injury in rat liver was examined by its application during the continual gamma irradiation (dose rates 0.2 and 0.6 Gy/day) or after acute gamma irradiation (dose 6 Gy). Silymarin influence was evaluated on the basis of mitotic index and chromosomal aberration frequency in the liver regenerating after partial hepatectomy. We have found that silymarin application stimulates the process of liver regeneration in non-irradiated rats as well as in irradiated ones. Positive effect of silymarin (100 mg per kg p.o. ones per day) was manifested at both dose rates of continual irradiation with increase in mitotic activity and mitigation of chromosomal erration frequency in the regenerating liver in comparison with non-protected irradiated animals. Curative effect of silymarin (70 mg/kg p.o., twice per day) was shown especially after 14 days of its postradiation application.
通过在连续γ射线照射（剂量率分别为0.2和0.6 Gy/天）期间或急性γ射线照射（剂量6 Gy）后应用水飞蓟宾（益肝灵），研究了其对大鼠肝脏潜在损伤发展和修复的辐射防护及治疗作用。基于部分肝切除术后肝脏再生中的有丝分裂指数和染色体畸变频率评估水飞蓟宾的影响。我们发现，应用水飞蓟宾可刺激未受辐射大鼠以及受辐射大鼠的肝脏再生过程。水飞蓟宾（每天口服100 mg/kg）在两种连续照射剂量率下均有积极作用，与未受保护的受辐射动物相比，再生肝脏中的有丝分裂活性增加，染色体畸变频率降低。水飞蓟宾（每天口服70 mg/kg，分两次服用）的治疗效果尤其在辐射后应用14天后显现。
