[五例严重急性呼吸综合征患者的皮质类固醇治疗与胸部X线片变化]
[Corticosteroid therapy and changes in chest radiogram in five patients with severe acute respiratory syndrome].
作者信息
Zhang Jin, Yang Xia, Tan Hai, Zheng Xi-wei
机构信息
Department of Respiratory Medicine, Affiliated Hospital of Ningxia Medical College, Ningxia 750004, China.
出版信息
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003 Jun;15(6):346-8.
OBJECTIVE
To investigate the relationship between corticosteroid therapy and kinetic changes in chest X-ray in five patients with severe acute respiratory syndrome (SARS).
METHODS
With the identical underlying therapy (levofloxacin or ceftriaxone and macrolide), intravenous methylprednisolone was given at 80 mg twice a day in five patients, and its effect on the development of chest radiogram was observed.
RESULTS
Chest X-rays radiogram showed significant changes until peak stage (4-12 days) with the same doses of methylprednisolone, but it was dissolved consistently afterwards.
CONCLUSION
It is appeared that corticosteroid therapy has no marked effect on the development of chest radiogram in patients with SARS. It might indicate there is self-limited in course of SARS.
目的
研究5例严重急性呼吸综合征（SARS）患者中皮质类固醇治疗与胸部X线动态变化之间的关系。
方法
5例患者采用相同的基础治疗（左氧氟沙星或头孢曲松与大环内酯类药物），静脉注射甲泼尼龙，剂量为每日2次，每次80mg，观察其对胸部X线影像变化的影响。
结果
在使用相同剂量甲泼尼龙的情况下，胸部X线影像在高峰期（4 - 12天）出现显著变化，但之后持续消散。
结论
皮质类固醇治疗似乎对SARS患者胸部X线影像的变化没有显著影响。这可能表明SARS病程具有自限性。
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