Brooke Benjamin S, Bayes-Genis Antoni, Li Dean Y
Program in Human Molecular Biology and Genetics, Department of Medicine, University of Utah, Salt Lake City, UT 84112-5330, USA.
Trends Cardiovasc Med. 2003 Jul;13(5):176-81. doi: 10.1016/s1050-1738(03)00065-3.
Elastin is synthesized and secreted by vascular smooth muscle cells and is the major extracellular matrix component deposited in the arterial wall. When last reviewed by this journal in 1994, the link between elastin and a rare occlusive vascular disease had just been established. Since that time, it has become increasingly clear that elastin is a critical autocrine factor that maintains vascular homeostasis through a combination of biomechanical support and biologic signaling. This review examines the complexity of elastin-smooth muscle cell interactions, and how new insights may impact understanding of the pathogenesis and treatment of vascular disease.
弹性蛋白由血管平滑肌细胞合成并分泌，是沉积在动脉壁中的主要细胞外基质成分。该杂志上一次在1994年进行综述时，弹性蛋白与一种罕见的闭塞性血管疾病之间的联系刚刚被确立。从那时起，越来越清楚的是，弹性蛋白是一种关键的自分泌因子，通过生物力学支持和生物信号传导的组合来维持血管稳态。这篇综述探讨了弹性蛋白与平滑肌细胞相互作用的复杂性，以及新的见解如何可能影响对血管疾病发病机制和治疗的理解。
