Julius S, Gudbrandsson T
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor.
J Cardiovasc Pharmacol. 1992;20 Suppl 8:S40-8.
Whereas this review is based on the available evidence, interpretation of the data is entirely hypothetical and subjective. To a large degree the review reflects our long-standing fascination with the role of the sympathetic overactivity in hypertension. The basic tenet is that sympathetic overactivity in hypertension may lead to a number of secondary changes, all of which are conductive to coronary heart disease. We also propose that insulin resistance and hypertension are associated through an underlying hemodynamic abnormality and again find good evidence for a possible role of sympathetics in the genesis of such hemodynamic changes. Future research in our laboratory will be oriented toward experimental testing of various aspects of the proposed sympathetic overactivity/hypertension/insulin resistance hypothesis.
尽管本综述基于现有证据，但对数据的解读完全是假设性的且主观的。在很大程度上，该综述反映了我们长期以来对交感神经过度活跃在高血压中作用的着迷。基本观点是，高血压中的交感神经过度活跃可能导致一些继发性变化，所有这些变化都与冠心病有关。我们还提出，胰岛素抵抗和高血压通过潜在的血液动力学异常相关联，并且再次找到了交感神经在这种血液动力学变化发生中可能起作用的有力证据。我们实验室未来的研究将致力于对所提出的交感神经过度活跃/高血压/胰岛素抵抗假说的各个方面进行实验测试。
