Hypertension: a new perspective in therapy and metabolic effect. Part I.

Antihypertensive Therapy has been ineffective in reducing the incidence of coronary artery disease. It has been suggested that the metabolic and biochemical alterations induced by some antihypertensive drugs may be responsible for their failure to reduce cardiovascular mortality in patients with hypertension. Hypertension is only one of multiple coronary risk factors associated to insulin resistance. This cluster of risk factors is call "The Syndrome of Insulin Resistance" by some and "Syndrome X" by Reaven and others. Is important to know this information when pharmacological antihypertensive therapy is contemplated.