• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment.

作者信息

Sambamurti K, Refolo L M, Shioi J, Pappolla M A, Robakis N K

机构信息

Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029.

出版信息

Ann N Y Acad Sci. 1992 Dec 31;674:118-28. doi: 10.1111/j.1749-6632.1992.tb27481.x.

DOI:10.1111/j.1749-6632.1992.tb27481.x
PMID:1283818
Abstract
摘要

相似文献

1
The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment.
Ann N Y Acad Sci. 1992 Dec 31;674:118-28. doi: 10.1111/j.1749-6632.1992.tb27481.x.
2
The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells.阿尔茨海默病β-淀粉样蛋白前体/蛋白酶nexin-II在人神经胶质瘤细胞的反式高尔基体分泌区室中被分泌酶切割。
Biochem J. 1993 Oct 15;295 ( Pt 2)(Pt 2):367-78. doi: 10.1042/bj2950367.
3
Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells.阿尔茨海默病淀粉样前体蛋白被α-分泌酶切割发生在神经元细胞表面。
Biochemistry. 1999 Jul 27;38(30):9728-34. doi: 10.1021/bi9906827.
4
Cellular processing and proteoglycan nature of amyloid precursor proteins.淀粉样前体蛋白的细胞加工与蛋白聚糖性质
Ann N Y Acad Sci. 1993 Sep 24;695:132-8. doi: 10.1111/j.1749-6632.1993.tb23041.x.
5
Metabolites of the beta-amyloid precursor protein generated by beta-secretase localise to the trans-Golgi network and late endosome in 293 cells.
J Neurosci Res. 1996 Oct 15;46(2):211-25. doi: 10.1002/(SICI)1097-4547(19961015)46:2<211::AID-JNR9>3.0.CO;2-K.
6
Pulse-chase experiments revealed beta-secretase cleavage from immature full-length amyloid precursor protein harboring the Swedish mutation. Implications for distinct pathways.
J Mol Neurosci. 1998 Oct;11(2):141-50. doi: 10.1385/JMN:11:2:141.
7
A novel metalloprotease in rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments.大鼠脑中一种新型金属蛋白酶可切割阿尔茨海默病的淀粉样前体蛋白，产生淀粉样生成片段。
Biochemistry. 1997 Jan 7;36(1):156-63. doi: 10.1021/bi961848w.
8
Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases.酵母Yap3和Mkc7蛋白酶对β-淀粉样肽前体加工的表征
Biochim Biophys Acta. 1997 Nov 27;1359(2):110-22. doi: 10.1016/s0167-4889(97)00082-7.
9
Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells.PC12细胞中阿尔茨海默病淀粉样前体蛋白细胞内裂解的证据。
J Neurosci Res. 1992 Oct;33(2):319-29. doi: 10.1002/jnr.490330216.
10
How accelerated Golgi trafficking may drive Alzheimer's disease (comment on DOI 10.1002/bies.201400116).高尔基体运输加速如何引发阿尔茨海默病（评论DOI 10.1002/bies.201400116）
Bioessays. 2015 Mar;37(3):232-3. doi: 10.1002/bies.201400219. Epub 2015 Jan 19.

引用本文的文献

1
Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.β-淀粉样蛋白清除与降解（ABCD）途径及其在阿尔茨海默病中的作用。
Curr Alzheimer Res. 2015;12(1):32-46. doi: 10.2174/1567205012666141218140953.
2
Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein.新型部分 γ-分泌酶抑制机制诱导分泌型淀粉样β蛋白反常增加的证据。
PLoS One. 2014 Mar 21;9(3):e91531. doi: 10.1371/journal.pone.0091531. eCollection 2014.
3
Dual-tagged amyloid-β precursor protein reveals distinct transport pathways of its N- and C-terminal fragments.
双标记淀粉样前体蛋白揭示其N端和C端片段的不同运输途径。
Hum Mol Genet. 2014 Mar 15;23(6):1631-43. doi: 10.1093/hmg/ddt555. Epub 2013 Nov 7.
4
Cellular mechanisms of γ-secretase substrate selection, processing and toxicity.γ-分泌酶底物选择、加工和毒性的细胞机制。
Prog Neurobiol. 2012 Aug;98(2):166-75. doi: 10.1016/j.pneurobio.2012.05.006. Epub 2012 May 20.
5
Amyloid-Beta interaction with mitochondria.淀粉样β蛋白与线粒体的相互作用。
Int J Alzheimers Dis. 2011 Mar 15;2011:925050. doi: 10.4061/2011/925050.
6
Targets for AD treatment: conflicting messages from γ-secretase inhibitors.AD 治疗靶点：γ-分泌酶抑制剂的相互矛盾的信息。
J Neurochem. 2011 May;117(3):359-74. doi: 10.1111/j.1471-4159.2011.07213.x. Epub 2011 Mar 15.
7
The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.淀粉样前体蛋白的裂解产物被分选到不同的载体囊泡中，这些囊泡在神经突内独立运输。
J Neurosci. 2009 Mar 18;29(11):3565-78. doi: 10.1523/JNEUROSCI.2558-08.2009.
8
Insulysin cleaves the APP cytoplasmic fragment at multiple sites.
Neurochem Res. 2007 Dec;32(12):2225-34. doi: 10.1007/s11064-007-9449-z. Epub 2007 Aug 15.
9
Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease.阿尔茨海默病中β-淀粉样蛋白的细胞与分子生物学进展
Neuromolecular Med. 2002;1(1):1-31. doi: 10.1385/NMM:1:1:1.
10
Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport.阿尔茨海默病的关键因素：β-淀粉样前体蛋白的加工、代谢及神经元内运输
Brain Pathol. 2001 Jan;11(1):1-11. doi: 10.1111/j.1750-3639.2001.tb00376.x.