Chen Dianjun, Timmons Cody, Wei Han-Xun, Li Guigen
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, USA.
J Org Chem. 2003 Jul 11;68(14):5742-5. doi: 10.1021/jo030098a.
A new direct electrophilic diamination reaction of alpha,beta-unsaturated ketones and esters has been established without the use of any metal catalysts. Three types of nitriles (CH(3)CN, CH(3)CH(2)CN, and CH(3)CH(2)CH(2)CN) were employed as nucleophilic nitrogen sources. A new mechanism has also been proposed to explain the resulting regio- and stereoselectivity.
已经建立了一种新型的α,β-不饱和酮和酯的直接亲电二胺化反应，该反应无需使用任何金属催化剂。使用了三种类型的腈（CH(3)CN、CH(3)CH(2)CN和CH(3)CH(2)CH(2)CN）作为亲核氮源。还提出了一种新的机理解释所得到的区域选择性和立体选择性。
