在不使用任何金属催化剂的情况下对功能化烯烃进行直接亲电二胺化反应。
Direct electrophilic diamination of functionalized alkenes without the use of any metal catalysts.
作者信息
Chen Dianjun, Timmons Cody, Wei Han-Xun, Li Guigen
机构信息
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, USA.
出版信息
J Org Chem. 2003 Jul 11;68(14):5742-5. doi: 10.1021/jo030098a.
PMID:12839474
Abstract
A new direct electrophilic diamination reaction of alpha,beta-unsaturated ketones and esters has been established without the use of any metal catalysts. Three types of nitriles (CH(3)CN, CH(3)CH(2)CN, and CH(3)CH(2)CH(2)CN) were employed as nucleophilic nitrogen sources. A new mechanism has also been proposed to explain the resulting regio- and stereoselectivity.
摘要
已经建立了一种新型的α,β-不饱和酮和酯的直接亲电二胺化反应，该反应无需使用任何金属催化剂。使用了三种类型的腈（CH(3)CN、CH(3)CH(2)CN和CH(3)CH(2)CH(2)CN）作为亲核氮源。还提出了一种新的机理解释所得到的区域选择性和立体选择性。
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