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[维生素E琥珀酸酯诱导人胃癌SGC-7901细胞凋亡过程中caspase-8的表达及活性]

[The expression and activity of caspase-8 in the process of vitamin E succinate-induced apoptosis in human gastric carcinoma SGC-7901 cells].

作者信息

Li Yao, Wu Kun, Yu Wei-ping

机构信息

Nutrition and Food Department, Public Health College of Harbin Medical University, Harbin 150001, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Mar;37(2):112-4.

PMID:12839663
Abstract

OBJECTIVE

To investigate the role of caspase-8 in vitamin E succinate (VES)-induced apoptosis in human gastric carcinoma cells.

METHODS

The expression and activity of caspase-8 were measured by the Western Blot method with fluorescence and DAPI staining.

RESULTS

VES treatment induced the expression and activity of caspase-8 in a dose-dependent manner; the apoptosis ratio induced by VES was significantly decreased in SGC-7901 cells treated with caspase-8 inhibitor.

CONCLUSION

Caspase-8 plays an important role in SGC-7901 cell apoptosis induced by VES.

摘要

目的

探讨半胱天冬酶 -8（caspase-8）在维生素E琥珀酸酯（VES）诱导人胃癌细胞凋亡中的作用。

方法

采用蛋白质免疫印迹法、荧光染色法及4',6-二脒基-2-苯基吲哚（DAPI）染色法检测caspase-8的表达及活性。

结果

VES处理呈剂量依赖性诱导caspase-8的表达及活性；在用caspase-8抑制剂处理的SGC-7901细胞中，VES诱导的凋亡率显著降低。

结论

Caspase-8在VES诱导的SGC-7901细胞凋亡中起重要作用。

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Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Mar;37(2):112-4.
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