Yu Gong-huang, Ni Xing-hao, Qian Feng, Chen Li-hong
Department of Pathology, Red Cross Hospital, Hangzhou 310003, China.
Zhonghua Bing Li Xue Za Zhi. 2003 Apr;32(2):111-4.
To study the histogenesis and pathological characteristics of gastrointestinal stromal tumors (GIST) and GIST type stromal tumor (ST) beyond the gastrointestinal tract.
A retrospective study was carried out on leiomyoma, leiomyosarcoma and neurilemoma (46 cases in gastrointestinal tract and l3 cases in urinary tract and perineal area). 4 antibodies (CD117, CD34, SMA, S-100) were used for immunohistochemical staining.
Among 45 cases of GIST, the positive rate of CD117 and CD34 was 93.3% and 88.9% respectively. Among 12 cases of GIST type ST beyond the gastrointestinal tract, the positive rate of CD117 and CD34 was 83.3% and 75.0% respectively. In 2 cases (1 in gastrointestinal tract) of leiomyomas, both CD117 and CD 34 were negative in tumor cells, while SMA was extensively positive.
CD117 and CD34 positivity are the most valuable factors in diagnosing ST. Both GIST and GIST type ST beyond the gastrointestinal tract are considered originating from a proto-interstitial stem cell with disoriented differentiation.
研究胃肠道间质瘤（GIST）及胃肠道外GIST型间质瘤（ST）的组织发生及病理特征。
对平滑肌瘤、平滑肌肉瘤及神经鞘瘤进行回顾性研究（胃肠道46例，泌尿道及会阴区13例）。采用4种抗体（CD117、CD34、SMA、S - 100）进行免疫组化染色。
45例GIST中，CD117和CD34阳性率分别为93.3%和88.9%。12例胃肠道外GIST型ST中，CD117和CD34阳性率分别为83.3%和75.0%。2例平滑肌瘤（1例在胃肠道）中，肿瘤细胞CD117和CD34均为阴性，而SMA广泛阳性。
CD117和CD34阳性是诊断ST最有价值的因素。胃肠道间质瘤及胃肠道外GIST型间质瘤均被认为起源于分化紊乱的原始间质干细胞。
