伴有 Cajal 间质细胞的胃肠道浅表平滑肌瘤。

Superficial leiomyomas of the gastrointestinal tract with interstitial cells of Cajal.

作者信息

Janevska Vesna, Qerimi Adelina, Basheska Neli, Stojkova Elena, Janevski Vlado, Jovanovic Rubens, Zhivadinovik Julija, Spasevska Liljana

机构信息

Institute of Pathology, Faculty of Medicine Skopje, Republic of Macedonia.

Department for Histopathology and Clinical Cytology, University Clinic for Radiotherapy and Oncology Skopje, Republic of Macedonia.

出版信息

Int J Clin Exp Pathol. 2015 Dec 1;8(12):15977-84. eCollection 2015.

PMID:26884872

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4730085/

Abstract

OBJECTIVE

Some authors suggest common origin of gastrointestinal stromal tumors from stem cells, which may show diverse differentiation. There are reports in which cells morphologically identical to the interstitial cells of Cajal are found in deep leiomyomas. The aim of this study was to demonstrate CD117 positive cells in superficial gastrointestinal (GI) leiomyomas and to find other cells that would suggest diverse differentiation in histologically typical leiomyoma.

MATERIALS AND METHODS

We analyzed 8 cases of superficial leiomyomas and one deep leiomyoma, received in our institutions as endoscopically or surgically obtained material. The tumor sections were immunohistochemicaly stained with CD117, CD34, NF, S100, αSMA, desmin, caldesmon and mast cell antigen.

RESULTS

All leiomyomas showed diffuse positivity for αSMA, caldesmon and desmin. All of them had CD117 and CD34 positive cells morphologically identical to the interstitial cells of Cajal between smooth muscle fibers, 5 had S-100 and NF positive cells and 2 showed positivity for GFAP. The cells were found in different quantity; they were usually diffusely scattered through the tumors without predilection site, forming small groups in some areas.

CONCLUSION

CD177, CD34, S-100 and NF positive cells are present in superficial leiomyomas and they may suggest common origin of GI stromal tumors.

摘要

目的

一些作者认为胃肠道间质瘤起源于干细胞，可能表现出不同的分化。有报道称在深部平滑肌瘤中发现了形态与 Cajal 间质细胞相同的细胞。本研究的目的是证实浅表胃肠道平滑肌瘤中 CD117 阳性细胞的存在，并寻找其他提示组织学典型平滑肌瘤存在不同分化的细胞。

材料与方法

我们分析了 8 例浅表平滑肌瘤和 1 例深部平滑肌瘤，这些标本是通过内镜或手术获取的，来自我们的机构。肿瘤切片进行 CD117、CD34、NF、S100、αSMA、结蛋白、钙调蛋白和肥大细胞抗原的免疫组织化学染色。

结果

所有平滑肌瘤对 αSMA、钙调蛋白和结蛋白均呈弥漫性阳性。所有肿瘤均有形态与平滑肌纤维间 Cajal 间质细胞相同的 CD117 和 CD34 阳性细胞，5 例有 S - 100 和 NF 阳性细胞，2 例 GFAP 呈阳性。这些细胞数量不同；通常在肿瘤中弥漫性散在分布，无偏好部位，在某些区域形成小群。