Liu Q, Lu Z
Department of Cardiology, Tongji Hospital, Tongji Medical University, Wuhan 430030.
J Tongji Med Univ. 1999;19(1):40-1, 69. doi: 10.1007/BF02895592.
To evaluate the effect of Salvia Miltiorrhiza on coronary collateral circulation in dogs with experimental acute myocardial infarction, 12 dogs were randomly divided into Salvia Miltiorrhiza group (group D) and control group (group C). Acute myocardial infarction model was established in all dogs, Salvia Miltiorrhiza or saline was administered to the 2 groups respectively for 21 days. Coronary angiography was performed before and after ligation of coronary artery. The capillaries and distribution vessel density in tissue sections of myocardia were assessed. Angiography 2 h and 22 days after ligation of coronary artery revealed significant augmentation of collateral vessels, and capillaries and distribution vessel density in ischemic zone on day 22 showed statistically significant augmentation in group D as compared with that of controls (P < 0.05 and P < 0.01). It is concluded that Salvia Miltiorrhiza might improve the opening and formation of coronary collateral circulation of ischemic myocardia in dogs and thereby protecting myocardia from ischemia.
为评价丹参对实验性急性心肌梗死犬冠状动脉侧支循环的影响，将12只犬随机分为丹参组（D组）和对照组（C组）。所有犬均建立急性心肌梗死模型，分别对两组给予丹参或生理盐水，连续给药21天。在冠状动脉结扎前后进行冠状动脉造影。评估心肌组织切片中的毛细血管和分布血管密度。冠状动脉结扎后2小时和22天的血管造影显示侧支血管明显增多，与对照组相比，D组在第22天时缺血区的毛细血管和分布血管密度有统计学意义的增加（P<0.05和P<0.01）。结论：丹参可能改善犬缺血心肌冠状动脉侧支循环的开放和形成，从而保护心肌免受缺血损伤。
