Jia M J, Chen S L, Liao Y L, Liu D Q, Li L S, Zhao N P
Department of Gerontology, Xijing Hospital, China.
Zhongguo Yao Li Xue Bao. 1994 Sep;15(5):462-5.
Effects of furyl-dihydropyridine I (FDP-1) on collateral circulation were observed in ischemic myocardium of dogs. FDP-1 (200 micrograms.kg-1) of intracoronary injection increased collateral flow, reduced systemic artery resistance, and coronary systolic pressure in infarcted region and the area of infarction decreased from 28.9 +/- 1.3% to 15.3 +/- 1.2% (P < 0.01, n = 6). The results indicated that FDP-1 could improve coronary collateral circulation, increase collateral flow in ischemic region, decrease collateral flow in ischemic region, decrease myocardial oxygen demand, and protect myocardial ischemia.
观察了呋喃二氢吡啶I（FDP - 1）对犬缺血心肌侧支循环的影响。冠状动脉内注射FDP - 1（200微克·千克⁻¹）可增加侧支血流，降低体循环动脉阻力，梗死区域的冠状动脉收缩压降低，梗死面积从28.9±1.3%降至15.3±1.2%（P<0.01，n = 6）。结果表明，FDP - 1可改善冠状动脉侧支循环，增加缺血区域的侧支血流，降低心肌需氧量，并保护心肌缺血。
