Hu G, Yu S, Chen Y, Huang H, Hu C
Department of Oncology, Tongji Hospital, Tongji Medical University, Wuhan 430030.
J Tongji Med Univ. 2000;20(4):318-9. doi: 10.1007/BF02888190.
From March 1997 to November 1999, 45 patients with lung cancer were treated by a stereotactic radiotherapy, with 15 cases treated by a stereotactic radiotherapy alone, and 30 cases by the external radiotherapy plus stereotactic radiotherapy. The clinical target volume was 1.89-187.26 cm3 with the median being 18.17 cm3. The doses of plan target volume (PTV) edge was 16-30 Gy/2-3 times and the doses of center was 120% to 150% of PTV edge doses. The overall response rate was 84.4% (38/45), with 11 complete response (CR) and 27 partial response (PR). This study confirmed that the stereotactic radiotherapy is a safe and effective therapy for lung cancer. For those early-stage patients who can tolerate neither operation nor even conventional radiotherapy for various reasons, it can both achieve therapeutic purpose and improve quality of life.
1997年3月至1999年11月，45例肺癌患者接受了立体定向放射治疗，其中15例仅接受立体定向放射治疗，30例接受外照射加立体定向放射治疗。临床靶体积为1.89 - 187.26 cm³，中位数为18.17 cm³。计划靶体积（PTV）边缘剂量为16 - 30 Gy/2 - 3次，中心剂量为PTV边缘剂量的120%至150%。总有效率为84.4%（38/45），其中完全缓解（CR）11例，部分缓解（PR）27例。本研究证实立体定向放射治疗是一种安全有效的肺癌治疗方法。对于那些因各种原因既不能耐受手术甚至也不能耐受传统放疗的早期患者，它既能达到治疗目的又能提高生活质量。
