Lax I, Blomgren H, Näslund I, Svanström R
Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden.
Acta Oncol. 1994;33(6):677-83. doi: 10.3109/02841869409121782.
A method for stereotactic high-dose radiotherapy of malignancies in the abdomen has been developed. A stereotactic frame for the body has been developed and a method for fixation of the patient in the frame is described. The reproducibility in the stereotactic system of tumours in the liver and the lung was found to be within 5-8 mm for 90% of the patient set-ups. The diaphragmatic movements were reduced to 5-10 mm, by applying a pressure on the abdomen. An analytical method is used to calculate dose distributions for a continuum of beams in an isocentric treatment technique. The advantage of a heterogeneous target dose is demonstrated and proposed for the present application. A non-coplanar treatment technique, using eight individually shaped beams is proposed and has been used for patient treatments. The dose distribution for a patient with a metastasis in the liver is shown as well as dose volume histograms for the target and the liver.
已开发出一种用于腹部恶性肿瘤立体定向高剂量放疗的方法。已开发出一种用于身体的立体定向框架，并描述了将患者固定在该框架中的方法。对于90%的患者设置，发现肝脏和肺部肿瘤在立体定向系统中的再现性在5至8毫米范围内。通过对腹部施加压力，膈肌运动减少到5至10毫米。采用一种分析方法来计算等中心治疗技术中连续光束的剂量分布。展示了异质靶区剂量的优势并将其应用于当前情况。提出了一种使用八个单独塑形光束的非共面治疗技术，并已用于患者治疗。展示了一名肝脏转移患者的剂量分布以及靶区和肝脏的剂量体积直方图。
