索拉非尼A生物合成早期阶段的研究。

Investigation of the early stages in soraphen A biosynthesis.

作者信息

Hill Alison M, Thompson Betty L, Harris Jonathan P, Segret Roger

机构信息

Department of Chemistry, King's College London, Strand, London, UK WC2R 2LS.

出版信息

Chem Commun (Camb). 2003 Jun 21(12):1358-9. doi: 10.1039/b303542p.

DOI:10.1039/b303542p

PMID:12841240

Abstract

The unusual benzoate starter unit in soraphen A derives from phenylalanine via cinnamate in a beta-oxidative (plant-like) pathway; 3-phenyl-3-hydroxypropanoate incorporates directly into soraphen by loading onto module 2 of the PKS and indirectly from the beta-oxidative pathway to generate benzoyl CoA.

摘要

索拉芬 A 中不寻常的苯甲酸起始单元通过桂皮酸盐在β-氧化（类植物）途径中由苯丙氨酸衍生而来；3-苯基-3-羟基丙酸通过加载到聚酮合酶的模块 2 上直接并入索拉芬，也可从β-氧化途径间接生成苯甲酰辅酶 A。