Collins P, Billings C G, Barer G R, Daly J J, Jolly A
Cardiovasc Res. 1975 Nov;9(6):797-806. doi: 10.1093/cvr/9.6.797.
Small doses of isoprenaline sulphate given intermittently produce a characteristic cardiopathy consisting of subendocardial scarring and myocardial hypertrophy. A morphometric technique was successfully applied to the quantitation of these changes. This technique improves the use of the isoprenaline model for the study of cardiac necrosis as statistical analysis can be applied and objective comparisons made. No hypertrophy was seen in the absence of myocardial necrosis which suggests that it is at least in part compensatory.
间歇性给予小剂量硫酸异丙肾上腺素会产生一种特征性心脏病，包括心内膜下瘢痕形成和心肌肥大。一种形态计量技术被成功应用于这些变化的定量分析。该技术改进了异丙肾上腺素模型在心脏坏死研究中的应用，因为可以进行统计分析并进行客观比较。在没有心肌坏死的情况下未见肥大，这表明肥大至少部分是代偿性的。
