使用C2-半缩酮唾液酸供体进行脱水唾液酸化反应。

Dehydrative sialylation with C2-hemiketal sialyl donors.

作者信息

Haberman Jannine M, Gin David Y

机构信息

Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, Illinois 61801, USA.

出版信息

Org Lett. 2003 Jul 10;5(14):2539-41. doi: 10.1021/ol034815z.

DOI:10.1021/ol034815z

PMID:12841775

Abstract

[reaction: see text] A new method for sialylation involving the dehydrative coupling of sialyl donors with the reagent combination of (p-nitrophenyl)(phenyl) sulfoxide and triflic anhydride is reported. This process establishes sialyl C2-hemiketals as viable sialyl donors for complex carbohydrate synthesis.

摘要

[反应：见正文] 报道了一种新的唾液酸化方法，该方法涉及唾液酸供体与（对硝基苯基）（苯基）亚砜和三氟甲磺酸酐的试剂组合进行脱水偶联。该过程确立了唾液酸C2-半缩酮作为用于复杂碳水化合物合成的可行唾液酸供体。