Fluorous synthesis of hydantoins and thiohydantoins.
作者信息
Zhang Wei, Lu Yimin
机构信息
Fluorous Technologies, Inc., University of Pittsburgh Applied Research Center, 970 William Pitt Way, Pittsburgh, Pennsylvania 15238, USA.
出版信息
Org Lett. 2003 Jul 10;5(14):2555-8. doi: 10.1021/ol034854a.
Abstract
[reaction: see text] A fluorous synthesis of hydantoins is introduced. The reaction of perfluoroalkyl (Rfh)-tagged amino esters with an isocyanate is followed by the cyclization of ureas and simultaneous cleavage of the fluorous tag to afford hydantoins. The product purification is performed by solid-phase extraction over FluoroFlash cartridges, and no fluorous solvent is involved in either the reaction or the separation processes. The same method applies to synthesis of thiohydantoins.
摘要
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