硬皮菌素型苯并二氮杂䓬-喹唑啉酮的氟相合成
Fluorous synthesis of sclerotigenin-type benzodiazepine-quinazolinones.
作者信息
Zhang Wei, Williams John P, Lu Yimin, Nagashima Tadamichi, Chu Qainli
机构信息
Fluorous Technologies, Inc., University of Pittsburgh Applied Research Center, 970 William Pitt Way, Pittsburgh, PA 15238, USA.
出版信息
Tetrahedron Lett. 2007 Jan 22;48(4):563-565. doi: 10.1016/j.tetlet.2006.11.127.
Abstract
A new synthetic protocol for sclerotigenin-type benzodiazepine-quinazolinone library scaffold is introduced. A fluorous benzyl protecting group is used for synthesis of 4-benzodiazepine-2,5-dione intermediate and also as a phase tag for fluorous solid-phase extraction (F-SPE).
摘要
介绍了一种用于硬皮菌素型苯并二氮杂䓬-喹唑啉酮文库支架的新合成方案。一种氟代苄基保护基团用于合成4-苯并二氮杂䓬-2,5-二酮中间体，并且还用作氟固相萃取（F-SPE）的相标签。
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