1型人类免疫缺陷病毒临床分离株对抗逆转录病毒药物类别耐药频率的差异。
Differences in the frequency of resistance to antiretroviral drug classes among human immunodeficiency virus type 1 clinical isolates.
作者信息
Campo Rafael E, Lichtenberger Paola N, Rosa Isabella, Suarez German, Rivera Fernando A, Rodriguez Allan E, Jayaweera Dushyantha T, Wahlay Natalie A, Kolber Michael A
机构信息
Division of Infectious Diseases, University of Miami School of Medicine, Miami, Florida, USA.
出版信息
J Clin Microbiol. 2003 Jul;41(7):3376-8. doi: 10.1128/JCM.41.7.3376-3378.2003.
Abstract
Genotypic resistance to all antiretroviral classes was widespread among human immunodeficiency virus type 1 isolates failing therapy. Resistance to nonnucleoside reverse transcriptase inhibitors was found most frequently and resistance to protease inhibitors was found least frequently, most likely due to differences in the number of enzymatic amino acid substitutions leading to resistance to each particular drug class.
摘要
在接受治疗失败的1型人类免疫缺陷病毒分离株中，对所有抗逆转录病毒药物类别的基因型耐药性普遍存在。对非核苷类逆转录酶抑制剂的耐药性最为常见，而对蛋白酶抑制剂的耐药性最为少见，这很可能是由于导致对每种特定药物类别产生耐药性的酶促氨基酸替代数量存在差异。
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