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Highly active antiretroviral therapy failure and protease and reverse transcriptase human immunodeficiency virus type 1 gene mutations.高效抗逆转录病毒疗法失败与蛋白酶及1型人类免疫缺陷病毒逆转录酶基因突变
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HIV Protease Hinge Region Insertions at Codon 38 Affect Enzyme Kinetics, Conformational Stability and Dynamics.HIV 蛋白酶铰链区 38 位密码子的插入影响酶动力学、构象稳定性和动力学。
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In vitro cross-resistance profile of nucleoside reverse transcriptase inhibitor (NRTI) BMS-986001 against known NRTI resistance mutations.核苷逆转录酶抑制剂（NRTI）BMS-986001 对已知 NRTI 耐药突变的体外交叉耐药谱。
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HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.带有 20 种突变的 HIV-1 蛋白酶通过协调的结构重排表现出对临床抑制剂的极端耐药性。
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Current and Novel Inhibitors of HIV Protease.当前和新型 HIV 蛋白酶抑制剂。
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The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.逆转录酶核苷酸切除在HIV耐药性中的作用
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The remarkable frequency of human immunodeficiency virus type 1 genetic recombination.1型人类免疫缺陷病毒基因重组的显著频率。
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Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir.对蛋白酶抑制剂地瑞那韦耐药的人类免疫缺陷病毒临床分离株的分子特征分析
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本文引用的文献

1
New two-amino acid insertion near codon 70 of the HIV type 1 protease gene.
AIDS Res Hum Retroviruses. 2005 Apr;21(4):311-3. doi: 10.1089/aid.2005.21.311.
2
Rare one and two amino acid inserts adjacent to codon 103 of the HIV-1 reverse transcriptase (RT) affect susceptibility to non-nucleoside RT inhibitors.
Antivir Ther. 2005;10(2):363-6.
3
Increased multinucleoside drug resistance and decreased replicative capacity of a human immunodeficiency virus type 1 variant with an 8-amino-Acid insert in the reverse transcriptase.一种在逆转录酶中有8个氨基酸插入的1型人类免疫缺陷病毒变体，其多核苷耐药性增加且复制能力下降。
J Virol. 2005 Mar;79(6):3536-43. doi: 10.1128/JVI.79.6.3536-3543.2005.
4
Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication.人类免疫缺陷病毒1型逆转录酶中的Gln145Met/Leu变化赋予对核苷和非核苷类似物的抗性并损害病毒复制。
Antimicrob Agents Chemother. 2004 Dec;48(12):4611-7. doi: 10.1128/AAC.48.12.4611-4617.2004.
5
Amino acid insertions near Gag cleavage sites restore the otherwise compromised replication of human immunodeficiency virus type 1 variants resistant to protease inhibitors.在Gag裂解位点附近的氨基酸插入可恢复对蛋白酶抑制剂耐药的1型人类免疫缺陷病毒变体原本受损的复制能力。
J Virol. 2004 Nov;78(21):12030-40. doi: 10.1128/JVI.78.21.12030-12040.2004.
6
Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision.1型人类免疫缺陷病毒逆转录酶中Delta67复合突变对核苷类似物切除的影响
J Virol. 2004 Sep;78(18):9987-97. doi: 10.1128/JVI.78.18.9987-9997.2004.
7
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.一种萘啶羧酰胺为HIV-1整合酶机制相同的抑制剂之间的不一致耐药性提供了证据。
Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11233-8. doi: 10.1073/pnas.0402357101. Epub 2004 Jul 26.
8
Relative replication fitness of multi-nucleoside analogue-resistant HIV-1 strains bearing a dipeptide insertion in the fingers subdomain of the reverse transcriptase and mutations at codons 67 and 215.在逆转录酶的指状亚结构域带有二肽插入以及密码子67和215处发生突变的多核苷类似物耐药HIV-1毒株的相对复制适应性
Virology. 2004 Aug 15;326(1):103-12. doi: 10.1016/j.virol.2004.06.006.
9
Resistance to enfuvirtide, the first HIV fusion inhibitor.对恩夫韦肽（首个HIV融合抑制剂）的耐药性。
J Antimicrob Chemother. 2004 Aug;54(2):333-40. doi: 10.1093/jac/dkh330. Epub 2004 Jul 1.
10
Primer unblocking by HIV-1 reverse transcriptase and resistance to nucleoside RT inhibitors (NRTIs).HIV-1逆转录酶引发的引物解封及对核苷类逆转录酶抑制剂（NRTIs）的耐药性。
Int J Biochem Cell Biol. 2004 Sep;36(9):1687-705. doi: 10.1016/j.biocel.2004.02.028.

Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms.

作者信息

Winters Mark A, Merigan Thomas C

机构信息

Division of Infectious Diseases and Geographic Medicine, Stanford University, 300 Pasteur Drive, Room S-146, Stanford, California 94305-5107, USA.

出版信息

Antimicrob Agents Chemother. 2005 Jul;49(7):2575-82. doi: 10.1128/AAC.49.7.2575-2582.2005.

DOI:10.1128/AAC.49.7.2575-2582.2005
PMID:15980322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1168704/
Abstract
摘要