Ruthazer Edward S, Akerman Colin J, Cline Hollis T
Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Science. 2003 Jul 4;301(5629):66-70. doi: 10.1126/science.1082545.
To determine how patterned visual activity regulates the development of axonal projections, we collected in vivo time-lapse images of retinal axons from albino Xenopus tadpoles in which binocular innervation of the optic tectum was induced. Axons added branch tips with nearly equal probability in all territories, but eliminated them preferentially from territory dominated by the opposite eye. This selective branch elimination was abolished by blockade of N-methyl-D-aspartate receptors. These results describe a correlation-based mechanism by which visual experience directly governs axon branch dynamics that contribute to the development of topographic maps.
为了确定模式化视觉活动如何调节轴突投射的发育，我们收集了来自白化非洲爪蟾蝌蚪视网膜轴突的体内延时图像，其中诱导了视顶盖的双眼神经支配。轴突在所有区域添加分支尖端的概率几乎相等，但优先从对侧眼主导的区域消除它们。这种选择性分支消除通过N-甲基-D-天冬氨酸受体的阻断而被消除。这些结果描述了一种基于相关性的机制，通过该机制视觉经验直接控制有助于地形图发育的轴突分支动态。
