Vasu Govardhana Reddy Peddaiahgari, Suresh Reddy Cirandur, Naga Raju Chamarthi
Department of Chemistry, Sri Venkateswara University College of Engineering, Tirupati, India.
Chem Pharm Bull (Tokyo). 2003 Jul;51(7):860-3. doi: 10.1248/cpb.51.860.
N-(substituted)-N'-(2,3-dihydro-5-benzoyl-2-oxido-1H-1,3,2-benzodiazaphosphol-2-yl) ureas were synthesized by reacting 3,4-diaminobenzophenone (4) with different chlorides of carbamidophosphoric acids (3) in the presence of triethylamine at 40-45 degrees C. Their 1H-, 13C- and 31P-NMR spectral data are discussed. The title compounds were screened for antifungal and antibacterial activity against the fungi Aspergillus niger and Fusarium solani and bacteria Escherichia coli and Staphylococcus aureus. These compounds showed higher antibacterial activity when compared with antifungal activity.
通过在40 - 45摄氏度下，使3,4 - 二氨基二苯甲酮（4）与不同的氨基甲酰磷酸氯化物（3）在三乙胺存在下反应，合成了N - （取代基） - N' - （2,3 - 二氢 - 5 - 苯甲酰基 - 2 - 氧化 - 1H - 1,3,2 - 苯并二氮杂磷杂环戊 - 2 - 基）脲。讨论了它们的1H - 、13C - 和31P - NMR光谱数据。针对黑曲霉、茄病镰刀菌等真菌以及大肠杆菌和金黄色葡萄球菌等细菌，对标题化合物进行了抗真菌和抗菌活性筛选。与抗真菌活性相比，这些化合物显示出更高的抗菌活性。
