苯并咪唑的一些异羟肟酸衍生物的合成及其抗菌和抗真菌活性。
Synthesis of some hydroxamic acid derivatives of benzimidazole and their antibacterial and antifungal activities.
作者信息
Güneş H S, Coşar G
机构信息
Department of Pharmaceutical Chemistry, Ege University, Faculty of Pharmacy, Bornova-Izmir, Turkey.
出版信息
Arzneimittelforschung. 1992 Aug;42(8):1045-8.
A number of 1H-benzimidazole-2-propanoic acid derivatives have been synthesized by Phillips method, and their antibacterial and antifungal activities have been tested. The chemical structures of the synthesized compounds were elucidated by spectroscopic (IR, NMR, mass) and elementary analysis. Investigation of antimicrobial activity of the compounds was done by agar dilution technique using bacteria (Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Mycobacterium smegmatis ATCC 607) and yeast-like fungi (Candida albicans, Candida tropicalis, Candida pseudotropicalis, Candida kruzei, Candida globrata). Among the compounds tested N-hydroxy-3-(1H-benzimidazol-2-yl)-propionamide (Compound 6) showed considerable activity against both Candida albicans and Candida tropicalis.
通过菲利普斯方法合成了多种1H-苯并咪唑-2-丙酸衍生物，并测试了它们的抗菌和抗真菌活性。通过光谱（红外、核磁共振、质谱）和元素分析确定了合成化合物的化学结构。使用细菌（金黄色葡萄球菌ATCC 25923、大肠杆菌ATCC 25922、铜绿假单胞菌ATCC 27853、耻垢分枝杆菌ATCC 607）和酵母样真菌（白色念珠菌、热带念珠菌、假热带念珠菌、克柔念珠菌、光滑念珠菌），采用琼脂稀释技术对化合物的抗菌活性进行了研究。在所测试的化合物中，N-羟基-3-(1H-苯并咪唑-2-基)-丙酰胺（化合物6）对白色念珠菌和热带念珠菌均表现出相当强的活性。
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