Friedrichs Nicolaus, Vorreuther Roland, Fischer Hans-Peter, Wiestler Otmar D, Buettner Reinhard
Institute of Pathology, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.
Virchows Arch. 2003 Aug;443(2):217-9. doi: 10.1007/s00428-003-0852-9. Epub 2003 Jul 3.
Central neurocytoma represents a rare neoplasm of the central nervous system with advanced neurocytic and sometimes focal lipomatous differentiation, a low proliferative potential and a favorable prognosis depending on the efficiency of surgical resection. This entity has been described as an intraventricular tumor near the foramen Monroi. Here, we report a case of a 21-year-old male with peripheral neurocytoma. Using computed tomography, a tumor of unknown origin was located behind the bladder. After complete surgical resection of the tumor, histologically small uniform cells, zones of fibrillarity and neuropil-like islands were seen. Immunohistochemistry revealed positivity for the neuronal markers synaptophysin, neuron-specific enolase and neurofilaments. Vimentin, pan-keratin, desmin, chromogranin, CD-99 and glial fibrillary acidic protein were immuno-negative. A low proliferation rate (1-2%) was found. Several case reports described extraventricular central neurocytomas. A sole publication documented a peripheral neurocytoma arising within a mature cystic teratoma of the ovary. To our knowledge, this is the second reported case of a neurocytoma outside the central nervous system, indicating that this entity may also occur infrequently in peripheral tissues.
中枢神经细胞瘤是一种罕见的中枢神经系统肿瘤，具有高级神经细胞分化，有时伴有局灶性脂肪化生，增殖潜能低，其预后取决于手术切除的效果。该实体瘤被描述为位于孟氏孔附近的脑室内肿瘤。在此，我们报告一例21岁男性外周神经细胞瘤病例。通过计算机断层扫描，在膀胱后方发现了一个来源不明的肿瘤。肿瘤完整切除后，组织学检查可见小而均匀的细胞、纤维状区域和神经毡样岛。免疫组织化学显示神经元标志物突触素、神经元特异性烯醇化酶和神经丝呈阳性。波形蛋白、泛角蛋白、结蛋白、嗜铬粒蛋白、CD-99和胶质纤维酸性蛋白免疫阴性。发现增殖率较低（1%-2%）。几例病例报告描述了脑室外中枢神经细胞瘤。仅有一篇文献记录了发生在卵巢成熟囊性畸胎瘤内的外周神经细胞瘤。据我们所知，这是第二例报道的中枢神经系统外神经细胞瘤病例，表明该实体瘤在外周组织中也可能罕见发生。
