Hirschowitz L, Ansari A, Cahill D J, Bamford D S, Love S
Department of Cellular Pathology, Royal United Hospital, Bath, England.
Int J Gynecol Pathol. 1997 Apr;16(2):176-9. doi: 10.1097/00004347-199704000-00016.
Tumors of central nervous system elements are uncommon in cystic teratomas and tend to be derived from glial or primitive neuroectodermal cells. We describe the case of a 23-year-old woman with a central neurocytoma arising in an otherwise mature cystic teratoma of the ovary. Histologically, the neurocytoma was composed of collections of oligodendroglioma like cells in a fibrillary matrix. Cytologically the tumor was identical in appearance to central neurocytomas occurring within the adult brain. It expressed synaptophysin and neuron-specific enolase, confirming its neuronal lineage, but not glial fibrillary acidic protein. The site of the tumor recapitulated the typical location of neurocytomas adjacent to the lateral ventricle in that in abutted onto an ependyma-lined cyst within the teratoma. The patient remains well and free of tumor 1 year after cystectomy, in keeping with favorable follow-up data for surgically excised central neurocytomas within the brain.
中枢神经系统成分的肿瘤在囊性畸胎瘤中并不常见，且往往起源于神经胶质细胞或原始神经外胚层细胞。我们描述了一名23岁女性的病例，其卵巢成熟囊性畸胎瘤中发生了中枢神经细胞瘤。组织学上，神经细胞瘤由纤维状基质中类似少突胶质细胞瘤的细胞聚集组成。细胞学上，该肿瘤外观与成人大脑内发生的中枢神经细胞瘤相同。它表达突触素和神经元特异性烯醇化酶，证实其神经元谱系，但不表达胶质纤维酸性蛋白。肿瘤的位置重现了神经细胞瘤在侧脑室附近的典型位置，因为它紧邻畸胎瘤内由室管膜衬里的囊肿。该患者在囊肿切除术后1年情况良好，无肿瘤复发，这与脑内手术切除的中枢神经细胞瘤的良好随访数据一致。
