Hendry I A, Messina A, Bell C
Department of Physiology, University of Melbourne Medical Centre, Parkville, Vic. Australia.
Neurosci Lett. 1992 Dec 14;148(1-2):117-20. doi: 10.1016/0304-3940(92)90818-r.
We treated rat pups with nerve growth factor (10 micrograms/animal/day s.c.) over postnatal days 1-7. Subsequent adult neuron numbers and tyrosine hydroxylase content in superior cervical ganglion were normal, but preganglionic inputs, as gauged from ganglionic choline acetyltransferase, were reduced. In parallel, intraganglionic axon terminals containing calcitonin gene-related peptide, but not those containing substance P, were increased in number. We postulate that neonatal nerve growth factor stimulates sprouting of ingrowing axons that have entered the ganglion soon after birth and that this represses subsequent establishment of cholinergic preganglionic synapses.
我们在出生后第1至7天，用神经生长因子（10微克/动物/天，皮下注射）处理新生大鼠幼崽。随后，颈上神经节中的成年神经元数量和酪氨酸羟化酶含量正常，但从神经节胆碱乙酰转移酶测量的节前输入减少。同时，含有降钙素基因相关肽的神经节内轴突终末数量增加，而含有P物质的轴突终末数量未增加。我们推测，新生期神经生长因子刺激出生后不久进入神经节的生长中轴突发芽，这会抑制随后胆碱能节前突触的建立。
