McGeer E G, Singh E A, McGeer P L
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Neurosci Lett. 1992 Dec 14;148(1-2):31-3. doi: 10.1016/0304-3940(92)90797-b.
Five hours after the stereotaxic injection of approximately 1 ng of [125I]basic fibroblast growth factor (bFGF) into rat substantia nigra (SN), small but consistent amounts of radioactivity were found in the ipsilateral striatum (CP). None was found in the ipsilateral thalamus or contralateral CP, SN or thalamus. The amount found in the ipsilateral CP was very markedly reduced in rats injected 5-7 days after 6-hydroxydopamine-induced lesions of the nigrostriatal dopaminergic tract but was unaffected by prior kainic acid lesion of the CP. No radioactivity was found in the ipsilateral SN 5 h after injections of similar amounts of radioactive bFGF into the CP. These results are consistent with anterograde transport of bFGF in the dopaminergic nigrostriatal tract.
将约1纳克的[125I]碱性成纤维细胞生长因子（bFGF）立体定向注射到大鼠黑质（SN）5小时后，在同侧纹状体（CP）中发现了少量但持续的放射性。在同侧丘脑、对侧CP、SN或丘脑中均未发现放射性。在6-羟基多巴胺诱导黑质纹状体多巴胺能通路损伤后5-7天注射的大鼠中，同侧CP中发现的放射性量显著减少，但不受CP先前 kainic 酸损伤的影响。向CP注射相似量的放射性bFGF 5小时后，在同侧SN中未发现放射性。这些结果与bFGF在多巴胺能黑质纹状体通路中的顺行运输一致。
