Bruisten Sylvia M
GG&GD Municipal Health Service, Department of Public Health Laboratory, Nieuwe Achtergracht 100, 1018 WT Amsterdam, The Netherlands.
Curr Womens Health Rep. 2003 Aug;3(4):288-98.
Women who are in a low socioeconomic status are most vulnerable to genital ulcer disease (GUD). GUD is recognized as an important co-factor for acquisition of HIV. GUD etiology has been elucidated in the past decade, with the availability of multiplex polymerase chain reaction. Worldwide, herpes simplex virus-2 (HSV-2) is the leading cause of GUD. However, mainly in women in developed countries, the incidence of GUD causation by HSV-1 is rising, owing to adolescents who are HSV-1 naïve and to increased oral sex practices. Especially in some African countries, the still high prevalence of chancroid should decrease in the next decade, because chancroid can easily be avoided and treated. Syphilitic ulcers seemed to be almost extinct, but recently there has been a resurgence of syphilis worldwide with the availability of effective HIV treatment. Development of herpes and chancroid vaccines, condom use, and the provision of education and accessible treatment facilities should help those women who now suffer from recurrent GUD infections.
社会经济地位较低的女性最易感染生殖器溃疡疾病（GUD）。GUD被认为是感染艾滋病毒的一个重要辅助因素。在过去十年中，随着多重聚合酶链反应技术的出现，GUD的病因已得到阐明。在全球范围内，单纯疱疹病毒2型（HSV-2）是GUD的主要病因。然而，主要在发达国家的女性中，由于初发HSV-1的青少年以及口交行为的增加，由HSV-1引起的GUD发病率正在上升。特别是在一些非洲国家，软下疳的高流行率在未来十年应会下降，因为软下疳很容易预防和治疗。梅毒溃疡似乎几乎绝迹，但最近随着有效抗艾滋病毒治疗方法的出现，梅毒在全球范围内再度流行。开发疱疹和软下疳疫苗、使用避孕套以及提供教育和可及的治疗设施应有助于那些目前患有复发性GUD感染的女性。
