Potter Dara, Goldenberg Robert L, Read Jennifer S, Wang Jing, Hoffman Irving F, Saathoff Elmar, Kafulafula George, Aboud Said, Martinson Francis E A, Dahab Maysoon, Vermund Sten H
School of Public Health, University of Alabama at Birmingham, USA.
Sex Transm Dis. 2006 Oct;33(10):604-9. doi: 10.1097/01.olq.0000216029.00424.ae.
The objectives of this cross-sectional study were to determine correlates of syphilis seroprevalence among HIV-infected and -uninfected antenatal attendees in an African multisite clinical trial, and to improve strategies for maternal syphilis prevention.
A total of 2,270 (86%) women were HIV-infected and 366 (14%) were HIV-uninfected. One hundred seventy-five (6.6%) were syphilis-seropositive (7.3% among HIV-infected and 2.6% HIV-uninfected women). Statistically significant correlates included geographic site (odds ratio [OR] = 4.5, Blantyre; OR = 3.2, Lilongwe; OR = 9.0, Lusaka vs. Dar es Salaam referent); HIV infection (OR = 3.3); age 20 to 24 years (OR = 2.5); being divorced, widowed, or separated (OR = 2.9); genital ulcer treatment in the last year (OR = 2.9); history of stillbirth (OR = 2.8, one stillbirth; OR = 4.3, 2-5 stillbirths); and history of preterm delivery (OR = 2.7, one preterm delivery).
Many women without identified risk factors were syphilis-seropositive. Younger HIV-infected women were at highest risk. Universal integrated antenatal HIV and syphilis screening and treatment is essential in sub-Saharan African settings.
本横断面研究的目的是确定在一项非洲多中心临床试验中，感染和未感染艾滋病毒的产前检查者中梅毒血清阳性率的相关因素，并改进预防孕产妇梅毒的策略。
共有2270名（86%）妇女感染艾滋病毒，366名（14%）未感染艾滋病毒。175名（6.6%）梅毒血清学检测呈阳性（感染艾滋病毒的妇女中为7.3%，未感染艾滋病毒的妇女中为2.6%）。具有统计学意义的相关因素包括地理位置（比值比[OR]=4.5，布兰太尔；OR=3.2，利隆圭；OR=9.0，卢萨卡与达累斯萨拉姆对照）；艾滋病毒感染（OR=3.3）；年龄20至24岁（OR=2.5）；离婚、丧偶或分居（OR=2.9）；过去一年接受过生殖器溃疡治疗（OR=2.9）；死产史（OR=2.8，一次死产；OR=4.3，2至5次死产）；以及早产史（OR=2.7，一次早产）。
许多无明确危险因素的妇女梅毒血清学检测呈阳性。感染艾滋病毒的年轻妇女风险最高。在撒哈拉以南非洲地区，普遍开展综合产前艾滋病毒和梅毒筛查及治疗至关重要。
