染色质不断变化的面貌。

The constantly changing face of chromatin.

作者信息

Vaquero Alejandro, Loyola Alejandra, Reinberg Danny

机构信息

Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

出版信息

Sci Aging Knowledge Environ. 2003 Apr 9;2003(14):RE4. doi: 10.1126/sageke.2003.14.re4.

DOI:10.1126/sageke.2003.14.re4

PMID:12844523

Abstract

Many recent findings have altered our vision of chromatin and its role in the regulation of cellular functions. Our perspective concerning chromatin has changed to a much more complex, but also more dynamic, view of chromatin as an entity that is intimately involved in the regulation of a variety of cellular functions. In this review, we describe the various types of proteins that alter the structure and, therefore, the function of chromatin and discuss the possible role of chromatin in cell aging. The elucidation of the mechanisms that link chromatin to aging will be one of the most exciting and striking advancements in the coming years

摘要

最近的许多发现改变了我们对染色质及其在细胞功能调控中作用的看法。我们对染色质的认知已转变为一种更为复杂但也更具动态性的观点，即染色质是一个紧密参与多种细胞功能调控的实体。在这篇综述中，我们描述了改变染色质结构进而影响其功能的各类蛋白质，并探讨了染色质在细胞衰老中可能发挥的作用。阐明将染色质与衰老联系起来的机制将是未来几年最令人兴奋和瞩目的进展之一。