染色质破坏与修饰
Chromatin disruption and modification.
作者信息
Wolffe A P, Hayes J J
机构信息
Laboratory of Molecular Embryology, Natational Institute of Child Health and Human Development, NIH, Building 18T, Room 106, Bethesda, MD 20892-5431, USA.
出版信息
Nucleic Acids Res. 1999 Feb 1;27(3):711-20. doi: 10.1093/nar/27.3.711.
Chromatin disruption and modification are associated with transcriptional regulation by diverse coactivators and corepressors. Here we discuss the possible structural basis and functional consequences of the observed alterations in chromatin associated with transcriptional activation and repression. Recent advances in defining the roles of individual histones and their domains in the assembly and maintenance of regulatory architectures provide a framework for understanding how chromatin remodelling machines, histone acetyltransferases and deacetylases function.
染色质的破坏与修饰与多种共激活因子和共抑制因子的转录调控相关。在此，我们讨论与转录激活和抑制相关的染色质中观察到的变化可能的结构基础和功能后果。在确定单个组蛋白及其结构域在调控结构的组装和维持中的作用方面的最新进展为理解染色质重塑机器、组蛋白乙酰转移酶和去乙酰化酶如何发挥作用提供了一个框架。
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