染色质中组蛋白H1功能的动力学
The dynamics of histone H1 function in chromatin.
作者信息
Bustin Michael, Catez Frédéric, Lim Jae-Hwan
机构信息
Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Mol Cell. 2005 Mar 4;17(5):617-20. doi: 10.1016/j.molcel.2005.02.019.
Over 80% of the nucleosomes in chromatin contain histone H1, a protein family known to affect the structure and activity of chromatin. Genetic studies and in vivo imaging experiments are changing the traditional view of H1 function and mechanism of action. H1 variants are partially redundant, mobile molecules that interact with nucleosomes as members of a dynamic protein network and serve as fine tuners of chromatin function.
染色质中超过80%的核小体含有组蛋白H1，这是一个已知会影响染色质结构和活性的蛋白质家族。遗传学研究和体内成像实验正在改变对H1功能和作用机制的传统看法。H1变体是部分冗余的可移动分子，它们作为动态蛋白质网络的成员与核小体相互作用，并充当染色质功能的微调器。
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