Padanilam B J, Stadler H S, Mills K A, McLeod L B, Solursh M, Lee B, Ramirez F, Buetow K H, Murray J C
Department of Biology, University of Iowa, Iowa City 52242.
Hum Mol Genet. 1992 Sep;1(6):407-10. doi: 10.1093/hmg/1.6.407.
cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified MboII and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.
