Serhatlioglu Selami, Kiris Adem, Kocakoc Ercan, Canpolat Ibrahim, Bozgeyik Zulkif, Han Mehmet Cengiz
Department of Radiology, Faculty of Medicine, Firat University, Elazig, Turkey.
Urol Int. 2003;71(1):103-7. doi: 10.1159/000071105.
Erectile dysfunction is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Oral use of sildenafil citrate has been proved to be effective in the treatment of erectile dysfunction. Although the effects of sildenafil citrate have been investigated in several studies, its effect on aortic, carotid and renal artery blood flow is unknown. The aim of this study was to investigate the early and late phase effects of sildenafil citrate on canine aortic, carotid and renal artery blood flow using color Doppler sonography (CDS).
A total of 6 healthy adult dogs was used in this study. With the aid of CDS peak systolic flow rate, end diastolic flow rate, resistivity index (RI) and pulsatility index in aortic, renal and carotid artery were determined before the administration of sildenafil citrate, 45-75 min after drug administration and after 15 days of drug administration. Data were statistically analyzed using Friedman and Wilcoxon rank tests. p < 0.05 was considered to be statistically significant.
Significant changes were determined in only 4 out of 28 parameters studied. The significantly changed parameters were as follows: a significant increase in the early and late phase of the postdrug peak of systolic aortic blood flow compared to values before drug administration, an increase in pre- and postdrug RI values of the aorta, a significant decrease in maximum velocity of the right carotid artery, and peak systolic maximum velocity of the left renal segmental artery after drug administration compared to their respective predrug basal values. The results from this study indicate that sildenafil citrate has no significant effects on aortic, renal and carotid artery blood flow rate either in the early or in the late phase. Since this study involved only 6 dogs there is a need for further clinical studies involving larger groups of subjects to conclude that this drug is safe with respect to the hemodynamic parameters evaluated in this study.
勃起功能障碍是指无法达到或维持足以实现满意性行为的勃起状态。口服枸橼酸西地那非已被证明对治疗勃起功能障碍有效。尽管在多项研究中已对枸橼酸西地那非的效果进行了调查，但其对主动脉、颈动脉和肾动脉血流的影响尚不清楚。本研究的目的是使用彩色多普勒超声（CDS）研究枸橼酸西地那非对犬主动脉、颈动脉和肾动脉血流的早期和晚期影响。
本研究共使用了6只健康成年犬。借助CDS，在给予枸橼酸西地那非之前、给药后45 - 75分钟以及给药15天后，测定主动脉、肾动脉和颈动脉的收缩期峰值流速、舒张末期流速、阻力指数（RI）和搏动指数。数据采用Friedman和Wilcoxon秩和检验进行统计学分析。p < 0.05被认为具有统计学意义。
在所研究的28个参数中，仅有4个出现了显著变化。显著变化的参数如下：与给药前的值相比，给药后主动脉收缩期血流峰值的早期和晚期均显著增加；主动脉给药前后的RI值增加；右侧颈动脉的最大流速显著降低；给药后左肾段动脉的收缩期峰值最大流速与其各自给药前的基础值相比降低。本研究结果表明，枸橼酸西地那非在早期或晚期对主动脉、肾动脉和颈动脉血流速率均无显著影响。由于本研究仅涉及6只犬，因此需要进一步开展涉及更大样本量受试者的临床研究，以得出该药物在本研究评估的血流动力学参数方面是安全的结论。
