Huang Jia-Qing, Hunt Richard H
Department of Medicine, Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario L8N 3Z5, Canada.
Can J Gastroenterol. 2003 Jun;17 Suppl B:18B-20B. doi: 10.1155/2003/692808.
The relationship between Helicobacter pylori infection and the risk of gastric cancer has been well established in the last decade. Four meta-analyses have found that the infection increases the risk of noncardia gastric cancer by 2- to 6-fold compared with noninfected control populations. However, the role of cagA strains of H pylori in relation to gastric cancer has not been evaluated systematically. We undertook a meta-analysis of epidemiological studies examining the relationship between infection with cagA-positive strains of H pylori and the risk of gastric cancer, and found that patients who are seropositive for cagA strains of H pylori are at an increased risk for developing noncardia gastric cancer compared with those with H pylori infection alone. Therefore, searching for cagA-positive strains of H pylori may help identify populations at a greater risk for developing gastric cancer.
在过去十年中，幽门螺杆菌感染与胃癌风险之间的关系已得到充分证实。四项荟萃分析发现，与未感染的对照人群相比，该感染使非贲门胃癌的风险增加了2至6倍。然而，幽门螺杆菌cagA菌株在胃癌方面的作用尚未得到系统评估。我们对流行病学研究进行了一项荟萃分析，以检验感染cagA阳性幽门螺杆菌菌株与胃癌风险之间的关系，结果发现，与仅感染幽门螺杆菌的患者相比，cagA菌株血清阳性的患者患非贲门胃癌的风险增加。因此，寻找cagA阳性幽门螺杆菌菌株可能有助于识别患胃癌风险更高的人群。
