胼胝体发育不全：产前诊断与预后
Agenesis of corpus callosum: prenatal diagnosis and prognosis.
作者信息
Moutard Marie-Laure, Kieffer Virginie, Feingold Josué, Kieffer François, Lewin Fanny, Adamsbaum Catherine, Gélot Antoinette, Campistol I Plana Jaume, van Bogaert Patrick, André Monique, Ponsot Gérard
机构信息
Services de Neuropédiatrie, Obstétrique, Radiologie, Hôpital Saint Vincent de Paul, 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France.
出版信息
Childs Nerv Syst. 2003 Aug;19(7-8):471-6. doi: 10.1007/s00381-003-0781-6. Epub 2003 Jul 4.
INTRODUCTION
Agenesis of corpus callosum (ACC) is commonly diagnosed prenatally. When isolated, it appears to carry a good prognosis but studies are often retrospective and follow-up short. We report a prospective study of 17 children (11 boys, 6 girls) with prenatally diagnosed isolated ACC.
METHODS
Neuropsychological evaluation was performed each year and results at the ages of 2, 4, and 6 years were compared.
RESULTS
Febrile seizures occurred in 3 patients. Median intellectual quotient (IQ) was within the normal range (80-109) and nonrelated to partial or complete ACC, sex, or febrile seizures. Lower median IQ was significantly related to low cultural status. With age, the number of children with IQ in the lower range (80-89) increased and slowness, attentional troubles, and instability appeared.
CONCLUSION
This study demonstrates that if outcome of isolated ACC is favorable, a long follow-up is necessary: with age, IQ in the lower range and behavioral troubles are linked to difficulties in school.
引言
胼胝体发育不全（ACC）通常在产前被诊断出来。当它单独出现时，似乎预后良好，但研究往往是回顾性的，且随访时间较短。我们报告了一项对17名产前诊断为孤立性ACC的儿童（11名男孩，6名女孩）的前瞻性研究。
方法
每年进行神经心理学评估，并比较2岁、4岁和6岁时的结果。
结果
3名患者发生热性惊厥。平均智商（IQ）在正常范围内（80 - 109），与部分或完全性ACC、性别或热性惊厥无关。较低的平均智商与低文化水平显著相关。随着年龄增长，智商处于较低范围（80 - 89）的儿童数量增加，并且出现了反应迟钝、注意力问题和情绪不稳定。
结论
这项研究表明，如果孤立性ACC的预后良好，进行长期随访是必要的：随着年龄增长，较低的智商范围和行为问题与学业困难有关。
Zotero 插件