Takanaga Hitomi, Mackenzie Bryan, Hediger Matthias A
Membrane Biology Program and Renal Division, Brigham & Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Pflugers Arch. 2004 Feb;447(5):677-82. doi: 10.1007/s00424-003-1104-1. Epub 2003 Jul 4.
l-Ascorbic acid (vitamin C) is an effective antioxidant and an essential cofactor in numerous enzymatic reactions. Two Na(+)-dependent vitamin C transporters (SVCT1 and SVCT2) are members of the SLC23 human gene family, which also contains two orphan members. SVCT1 and SVCT2 display similar properties, including high affinity for l-ascorbic acid, but are discretely distributed. SVCT1 is confined to epithelial systems including intestine, kidney, and liver, whereas SVCT2 serves a host of metabolically active and specialized cells and tissues including neurons, the eye, lung, and placenta, and a range of neuroendocrine, exocrine, and endothelial tissues. An SVCT2-knockout mouse reveals an obligatory requirement for SVCT2, but many of the specific roles of this transporter remain unclear.
L-抗坏血酸（维生素C）是一种有效的抗氧化剂，也是众多酶促反应中必不可少的辅助因子。两种钠依赖性维生素C转运蛋白（SVCT1和SVCT2）是SLC23人类基因家族的成员，该家族还包含两个孤儿成员。SVCT1和SVCT2具有相似的特性，包括对L-抗坏血酸的高亲和力，但分布不同。SVCT1局限于上皮系统，包括肠道、肾脏和肝脏，而SVCT2则存在于许多代谢活跃的特殊细胞和组织中，包括神经元、眼睛、肺和胎盘，以及一系列神经内分泌、外分泌和内皮组织。敲除SVCT2基因的小鼠显示出对SVCT2的绝对需求，但这种转运蛋白的许多具体作用仍不清楚。
